Clin Diagn Lab Immunol. 2005 Nov;12(11):1336-9.

Isolation and characterization of the promoter and partial enhancer region of the porcine inter-alpha-trypsin inhibitor heavy chain 4 gene.

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Institute of Biomedical and Life Sciences, Division of Infection and Immunity, University of Glasgow, United Kingdom. bhnhar@uniklinik-saarland.de

Abstract

A porcine genomic library was screened for clones containing the promoter of the major acute-phase protein in pigs, inter-alpha-trypsin heavy chain 4 (ITIH4). Following isolation of the promoter, a functional analysis was performed with Hep3B cells. The promoter was induced by interleukin-6 (IL-6) but not by IL-1beta. However, IL-1beta was shown to inhibit the IL-6-induced activation of the porcine ITIH4 promoter.

PMID:: 16275952; [PubMed - indexed for MEDLINE]
PMCID:: PMC1287766

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