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J Am Geriatr Soc. 2005 Nov;53(11):1881-8.

Should older people in residential care receive vitamin D to prevent falls? Results of a randomized trial.

Author information

  • 1School of Medicine and Pharmacology, University of Western Australia, Perth, Australia. leonflic@cyllene.uwa.edu.au

Abstract

OBJECTIVES:

To determine whether vitamin D supplementation can reduce the incidence of falls and fractures in older people in residential care who are not classically vitamin D deficient.

DESIGN:

Randomized, placebo-controlled double-blind, trial of 2 years' duration.

SETTING:

Multicenter study in 60 hostels (assisted living facilities) and 89 nursing homes across Australia.

PARTICIPANTS:

Six hundred twenty-five residents (mean age 83.4) with serum 25-hydroxyvitamin D levels between 25 and 90 nmol/L.

INTERVENTION:

Vitamin D supplementation (ergocalciferol, initially 10,000 IU given once weekly and then 1,000 IU daily) or placebo for 2 years. All subjects received 600 mg of elemental calcium daily as calcium carbonate.

MEASUREMENTS:

Falls and fractures recorded prospectively in study diaries by care staff.

RESULTS:

The vitamin D and placebo groups had similar baseline characteristics. In intention-to-treat analysis, the incident rate ratio for falling was 0.73 (95% confidence interval (CI)=0.57-0.95). The odds ratio for ever falling was 0.82 (95% CI=0.59-1.12) and for ever fracturing was 0.69 (95% CI=0.40-1.18). An a priori subgroup analysis of subjects who took at least half the prescribed capsules (n=540), demonstrated an incident rate ratio for falls of 0.63 (95% CI=0.48-0.82), an odds ratio (OR) for ever falling of 0.70 (95% CI=0.50-0.99), and an OR for ever fracturing of 0.68 (95% CI=0.38-1.22).

CONCLUSION:

Older people in residential care can reduce their incidence of falls if they take a vitamin D supplement for 2 years even if they are not initially classically vitamin D deficient.

Comment in

PMID:
16274368
[PubMed - indexed for MEDLINE]
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