Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Neuroreport. 2005 Nov 28;16(17):1959-62.

Analysis of hedgehog interacting protein in the brain and its expression in nitric oxide synthase-positive cells.

Author information

  • 1CNRS, Signal Transduction and Developmental Neuropharmacology, Laboratory of Cellular and Molecular Neurobiology, Alfred Fessard Institute of Neurobiology, Gif sur Yvette, France.

Abstract

Hedgehog interacting protein (Hip) and Patched 1 (Ptc1) regulate the cell responses to the morphogen Sonic Hedgehog (Shh). Here, we compare the relative expression patterns of Shh, Hip and Ptc1 transcripts in the E13.5 mouse brain embryo. We observe that the expression of Hip and Ptc1 often overlaps and is found close to Shh-expressing cells, suggesting that both proteins are required for controlling Shh signals. In the adult striatum in which Ptc1 is not detected, we show that a majority of Hip-expressing cells correspond to neurons expressing the neuronal form of nitric oxide synthase. These data raise the hypothesis for a functional link between nitric oxide and Shh signaling and for a nonredundant role of Hip and Ptc1 in the adult brain.

PMID:
16272887
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk