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J Matern Fetal Neonatal Med. 2005 Sep;18(3):167-72.

Risk of preeclampsia in relation to maternal history of migraine headaches.

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  • 1Center for Perinatal Studies, Swedish Medical Center, Seattle, Washington 98122, USA. kathryn7@u.washington.edu



We examined the relationship between migraines and preeclampsia risk.


Cases were 244 women with preeclampsia and controls were 470 normotensive women. Women were asked if a physician had ever told them that they had migraines. Odds ratios (OR) and 95% confidence intervals (CI) were calculated.


A history of migraines was associated with a 1.8-fold increased risk of preeclampsia (95% CI 1.1-2.7). Women who were 30+ years old when diagnosed with migraines had the highest risk (OR 2.8, 95% CI 0.8-9.0). The migraine-preeclampsia association appeared to be modified by pre-pregnancy overweight status (p = 0.06). Overweight migrainous women, compared with lean nonmigrainous women, had a 12-fold increased preeclampsia risk (95% CI 5.9-25.7).


Our findings are consistent with reports from six of eight previous studies on the topic. Nevertheless, prospective cohort studies are needed to further evaluate the extent to which migraines and/or its treatments are associated with preeclampsia risk.

[PubMed - indexed for MEDLINE]
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