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    Arzneimittelforschung. 1992 May;42(5A):732-8.

    Chronic toxicity studies of sertaconazole after oral administration to rats and ferrets.

    Romero A, Villamayor F, Grau MT, Sacristán A, Ortiz JA.

    Source

    Research Centre, Ferrer Group, Barcelona, Spain.

    Abstract

    Six-month chronic oral toxicity studies of 7-chloro-3-[1-(2, 4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethoxy-methyl] benzo[b]thiophene (sertaconazole, FI-7045, CAS 99592-32-2) were carried out in rats and ferrets. The dose levels used were 50, 150 and 300 mg/kg in rats and 50, 150 and 250 mg/kg in ferrets. There was no mortality associated with the drug in either of the two species. The results obtained show that the toxic effects may be summarized as a smaller body weight increase in rats at 150 and 300 mg/kg and in male ferrets at 250 mg/kg. Food consumption decreased significantly in rats at 300 mg/kg, and was not proportional to the doses of 150 and 50 mg/kg. In serum biochemistry, increases in alkaline phosphatase in rats, ALT in male ferrets at 150 and 250 mg/kg and AST only at 250 mg/kg were observed. BUN increased at 150 and 250 mg/kg in ferrets.

    PMID:
    1627194
    [PubMed - indexed for MEDLINE]

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