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Therapeutic considerations for Mdm2: not just a one trick pony.
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Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia.
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Mol Cell Biol. 2009 Apr; 29(8):2243-53. Epub 2009 Feb 17.
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ReviewUpdates on p53: modulation of p53 degradation as a therapeutic approach.
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Br J Cancer. 2008 Jan 15; 98(1):4-8. Epub 2008 Jan 8.
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