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    Pain Med. 2005 Sep-Oct;6(5):375-8.

    Topiramate for phantom limb pain: a time-series analysis.

    Harden RN, Houle TT, Remble TA, Lin W, Wang K, Saltz S.

    Source

    Center for Pain Studies, Rehabilitation Institute of Chicago/Northwestern University Medical School, Chicago, Illinois 60611, USA. nharden@rehabchicago.org

    Abstract

    There is growing evidence of topiramate's efficacy in treating neuropathic pain. This article reports a detailed analysis of the response of four amputee subjects with phantom limb pain. Individual time-series analyses revealed that three out of four amputee participants receiving topiramate had statistically significant decreases in pain, with the peak effect noted at 800 mg daily. This analysis supports a hypothesis that topiramate may be effective in reducing phantom limb pain, and suggests a definitive study is indicated.

    PMID:
    16266358
    [PubMed - indexed for MEDLINE]

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