Format

Send to:

Choose Destination
See comment in PubMed Commons below
EMBO Rep. 2005 Nov;6(11):1028-34.

The chromosome cycle: coordinating replication and segregation. Second in the cycles review series.

Author information

  • 1University of Dundee, Wellcome Trust Biocentre, Dow Street, Dundee DD1 5EH, UK. j.j.blow@dundee.ac.uk

Abstract

During the cell-division cycle, chromosomal DNA must initially be precisely duplicated and then correctly segregated to daughter cells. The accuracy of these two events is maintained by two interlinked cycles: the replication licensing cycle, which ensures precise duplication of DNA, and the cohesion cycle, which ensures correct segregation. Here we provide a general overview of how these two systems are coordinated to maintain genetic stability during the cell cycle.

PMID:
16264427
[PubMed - indexed for MEDLINE]
PMCID:
PMC1371039
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk