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    EMBO Rep. 2005 Nov;6(11):1028-34.

    The chromosome cycle: coordinating replication and segregation. Second in the cycles review series.

    Blow JJ, Tanaka TU.

    Source

    University of Dundee, Wellcome Trust Biocentre, Dow Street, Dundee DD1 5EH, UK. j.j.blow@dundee.ac.uk

    Abstract

    During the cell-division cycle, chromosomal DNA must initially be precisely duplicated and then correctly segregated to daughter cells. The accuracy of these two events is maintained by two interlinked cycles: the replication licensing cycle, which ensures precise duplication of DNA, and the cohesion cycle, which ensures correct segregation. Here we provide a general overview of how these two systems are coordinated to maintain genetic stability during the cell cycle.

    PMID:
    16264427
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC1371039
    Free PMC Article

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