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1: EMBO Rep. 2005 Nov;6(11):1028-34.Click here to read Click here to read Links

The chromosome cycle: coordinating replication and segregation. Second in the cycles review series.

Blow JJ, Tanaka TU.

University of Dundee, Wellcome Trust Biocentre, Dow Street, Dundee DD1 5EH, UK. j.j.blow@dundee.ac.uk

During the cell-division cycle, chromosomal DNA must initially be precisely duplicated and then correctly segregated to daughter cells. The accuracy of these two events is maintained by two interlinked cycles: the replication licensing cycle, which ensures precise duplication of DNA, and the cohesion cycle, which ensures correct segregation. Here we provide a general overview of how these two systems are coordinated to maintain genetic stability during the cell cycle.

PMID: 16264427 [PubMed - indexed for MEDLINE]

PMCID: PMC1371039