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Curr Opin Allergy Clin Immunol. 2005 Dec;5(6):525-30.

New insights into the mechanisms of allergen-specific immunotherapy.

Author information

  • 1Swiss Institute of Allergy and Asthma Research (SIAF), Davos, Switzerland. csweber@siaf.unizh.ch

Abstract

PURPOSE OF REVIEW:

Specific immunotherapy represents the only curative treatment of a specific allergy, and is therefore of great interest in terms of immunological mechanisms and therapeutic developments.

RECENT FINDINGS:

Allergen-specific regulatory T cells are induced after the initiation of specific immunotherapy, and are assumed to suppress effector T cells directly mediating allergic inflammation. Therefore regulatory T cells may play a key role in the re-induction of allergen tolerance. Multiple pathways in many systems are described to promote or enhance regulatory T cells. This review summarizes the current view on immunological mechanisms leading to and coming from regulatory T cells.

SUMMARY:

The highlighted mechanisms may not only contribute to improved specific immunotherapy, but also give insight into a clinically relevant therapy targeting regulatory T cells. The approach of addressing endogenous regulatory mechanisms specifically controlling inflammation instead of targeting inflammation itself is relevant for future pharmacological developments.

PMID:
16264333
[PubMed - indexed for MEDLINE]
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