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J Clin Endocrinol Metab. 2006 Jan;91(1):345-7. Epub 2005 Nov 1.

Correlation between testosterone and the inflammatory marker soluble interleukin-6 receptor in older men.

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  • 1Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21225, USA.

Abstract

CONTEXT:

An age-associated decline in testosterone (T) levels and an increase in proinflammatory cytokines contribute to chronic diseases in older men. Whether and how these changes are related is unclear.

OBJECTIVE:

We hypothesized that T and inflammatory markers are negatively correlated in older men.

DESIGN:

This was a cross-sectional study.

SETTING:

A population-based sample of older men was studied.

PARTICIPANTS AND MEASURES:

After excluding participants taking glucocorticoids or antibiotics or those with recent hospitalization, 467 men, aged 65 yr or older, had complete determinations of total T, bioavailable T, SHBG, albumin, IL-6, soluble IL-6 receptor (sIL-6r), TNF-alpha, IL-1beta, and C-reactive protein.

RESULTS:

After adjusting for potential confounders, sIL-6r was significantly and inversely correlated with total T (r = -0.20; P < 0.001) and bioavailable T (r = -0.12; P < 0.05). T was not correlated with any other inflammatory marker.

CONCLUSIONS:

These preliminary findings suggest an inverse relationship between T and sIL-6r. Longitudinal studies are needed to establish the causality of this association.

PMID:
16263825
[PubMed - indexed for MEDLINE]
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