Nat Rev Immunol. 2005 Nov;5(11):853-65.

Follicular B helper T cells in antibody responses and autoimmunity.

Vinuesa CG, Tangye SG, Moser B, Mackay CR.

Source

Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra 2601, Australia.

Abstract

T-cell help for B cells is essential for high-affinity antibody responses and B-cell memory. Recently, the identity of a discrete follicular population of T cells that has a crucial role in this process has become clearer. Similar to primed CD4(+) T cells in the tonsils and memory CD4(+) T cells in the peripheral blood, this follicular population of T cells expresses CXC-chemokine receptor 5 (CXCR5). Owing to their distinct homing preferences and helper function, these T cells differ from T helper 1 and T helper 2 cells and have been denoted follicular B helper T cells. Here, we outline the central role of this subset in normal and pathological immune responses.

PMID:: 16261173; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. [J Exp Med. 2000]
Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production.
Breitfeld D, Ohl L, Kremmer E, Ellwart J, Sallusto F, Lipp M, Förster R. J Exp Med. 2000 Dec 4; 192(11):1545-52.
CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. [J Exp Med. 2000]
CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function.
Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P, Moser B. J Exp Med. 2000 Dec 4; 192(11):1553-62.
Dissecting CXCR5+ T cell populations--on the quest for a better understanding of B cell help during T dependent antibody responses. [Eur J Immunol. 2006]
Dissecting CXCR5+ T cell populations--on the quest for a better understanding of B cell help during T dependent antibody responses.
Warnatz K. Eur J Immunol. 2006 Jul; 36(7):1662-4.
Review Lymphocyte traffic control by chemokines: follicular B helper T cells. [Immunol Lett. 2003]
Review Lymphocyte traffic control by chemokines: follicular B helper T cells.
Moser B, Ebert L. Immunol Lett. 2003 Jan 22; 85(2):105-12.
Review CXCR5(+) T cells: follicular homing takes center stage in T-helper-cell responses. [Trends Immunol. 2002]
Review CXCR5(+) T cells: follicular homing takes center stage in T-helper-cell responses.
Moser B, Schaerli P, Loetscher P. Trends Immunol. 2002 May; 23(5):250-4.

See reviews... See all...

Cited by 61 PubMed Central articles

Mobilization of natural killer cells inhibits development of collagen-induced arthritis. [Proc Natl Acad Sci U S A. 2011]
Mobilization of natural killer cells inhibits development of collagen-induced arthritis.
Leavenworth JW, Wang X, Wenander CS, Spee P, Cantor H. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14584-9. Epub 2011 Aug 22.
Noncanonical NF-kappaB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development. [Proc Natl Acad Sci U S A. 2011]
Noncanonical NF-kappaB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development.
Hu H, Wu X, Jin W, Chang M, Cheng X, Sun SC. Proc Natl Acad Sci U S A. 2011 Aug 2; 108(31):12827-32. Epub 2011 Jul 18.
Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression. [PLoS One. 2011]
Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression.
Serre K, Bénézech C, Desanti G, Bobat S, Toellner KM, Bird R, Chan S, Kastner P, Cunningham AF, Maclennan IC, et al. PLoS One. 2011; 6(6):e20731. Epub 2011 Jun 3.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Follicular B helper T cells in antibody responses and autoimmunity.
Follicular B helper T cells in antibody responses and autoimmunity.
Nat Rev Immunol. 2005 Nov ;5(11):853-65.

PubMed
Laser microdissection and microarray analysis of breast tumors reveal ER-alpha r...
Laser microdissection and microarray analysis of breast tumors reveal ER-alpha related genes and pathways.
Oncogene. 2006 Mar 2 ;25(9):1413-9.

PubMed
Reliability and validity of adapted Turkish Version of Scoliosis Research Societ...
Reliability and validity of adapted Turkish Version of Scoliosis Research Society-22 (SRS-22) questionnaire.
Spine (Phila Pa 1976). 2005 Nov 1 ;30(21):2464-8.

PubMed
[An autopsy study of patients who died at the Medical Clinic of the University o...
[An autopsy study of patients who died at the Medical Clinic of the University of Siena from 1986 to 1989].
Recenti Prog Med. 1992 Apr ;83(4):185-8.

PubMed
Aquatic plyometric training increases vertical jump in female volleyball players...
Aquatic plyometric training increases vertical jump in female volleyball players.
Med Sci Sports Exerc. 2005 Oct ;37(10):1814-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Follicular B helper T cells in antibody responses and autoimmunity.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 61 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information