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Ophthalmology. 2005 Dec;112(12):2219-24. Epub 2005 Oct 27.

Direct and noninvasive assessment of parafoveal capillary leukocyte velocity.

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  • 1College of Optometry, University of Houston, Houston, Texas, USA.

Abstract

PURPOSE:

Alterations in leukocyte velocity have been implicated in many retinal disease processes. However, direct and objective assessment of leukocyte velocity in retinal capillaries has been limited by a reliance on invasive contrast dyes that allow leukocyte visualization only for a short time span. The recent application of adaptive optics in a scanning laser ophthalmoscope (AOSLO) has made long-term imaging of parafoveal leukocyte movement possible without contrast dyes. In this study, using the AOSLO, we demonstrate a new method to investigate retinal parafoveal capillary leukocyte velocity.

DESIGN:

Experimental study.

PARTICIPANTS:

Six normal healthy subjects ranging from 25 to 35 years of age with clear ocular media.

METHODS:

The parafoveal zone of the retina was imaged in all subjects using an AOSLO.

MAIN OUTCOME MEASURES:

Leukocyte velocity was determined in the parafoveal capillaries including the foveal avascular zone border. Leukocyte velocity was measured directly from movie segments in which the leukocytes were clearly visible.

RESULTS:

The mean parafoveal leukocyte velocity for 6 subjects was 1.37 mm/second, ranging from 0.77 to 2.10 mm/second. Leukocytes were not visible in all parafoveal capillaries.

CONCLUSIONS:

Parafoveal capillary leukocyte velocity can be directly and noninvasively measured without the use of contrast dyes using an AOSLO.

PMID:
16257054
[PubMed - indexed for MEDLINE]
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