Display Settings:

Format

Send to:

Choose Destination
Science. 2005 Nov 18;310(5751):1152-8. Epub 2005 Oct 27.

Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes.

Author information

  • 1Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, L3.124, Dallas, TX 75390, USA.

Erratum in

  • Science. 2006 Feb 17;311(5763):954.

Abstract

Budding yeast grown under continuous, nutrient-limited conditions exhibit robust, highly periodic cycles in the form of respiratory bursts. Microarray studies reveal that over half of the yeast genome is expressed periodically during these metabolic cycles. Genes encoding proteins having a common function exhibit similar temporal expression patterns, and genes specifying functions associated with energy and metabolism tend to be expressed with exceptionally robust periodicity. Essential cellular and metabolic events occur in synchrony with the metabolic cycle, demonstrating that key processes in a simple eukaryotic cell are compartmentalized in time.

PMID:
16254148
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk