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1: Cancer Lett. 2005 Dec 8;230(1):20-4. Epub 2005 Jan 21.Click here to read Links

Association of human herpesvirus type 6 DNA with human bladder cancer.

Escudero AL, Luque RJ, Quintero A, Alvarez-Kindelan J, Requena MJ, Montironi R, Lopez-Beltran A.

Biomedical Research Unit, Cordoba University Medical School and Reina Sofia University Hospital, Avda. Menendez Pidal s/n, E-14004 Cordoba, Spain.

We examined the presence of human herpesvirus type 6 (HHV6) DNA in a series of 74 bladder carcinomas from a Mediterranean population to elucidate their possible role as cofactor in the development of bladder cancer with or without associated human papillomavirus (HPV) infection. HHV-6 type B DNA was present in 5 men (6.8%) out of the 74 tumors investigated; two of them had associated HPV-16 DNA in the same specimen. In one case that had associated urothelial carcinoma in situ, both HHV-6B and HPV-16 DNA were present. In conclusion, the low incidence of HHV-6B in bladder cancer and the ubiquitous nature of HHV-6 infection are more consistent with a bystander role rather than cofactor in the oncogenesis of bladder cancer.

PMID: 16253757 [PubMed - indexed for MEDLINE]

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