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Fitoterapia. 2005 Dec;76(7-8):722-4. Epub 2005 Oct 25.

Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice.

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  • 1Pharmaceutical Research Center, Faculty of Pharmacy, Mashad University of Medical Sciences, Mashhad, Iran.


The anticonvulsant activities of Crocus sativus stigma constituents, safranal and crocin, were evaluated in mice using pentylenetetrazole (PTZ)-induced convulsions in mice. Safranal (0.15 and 0.35 ml/kg, i.p.) reduced the seizure duration, delayed the onset of tonic convulsions and protected mice from death. Crocin (200 mg/kg, i.p.) did not show anticonvulsant activity.

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