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Nat Neurosci. 2005 Nov;8(11):1442-4.

Plasticity of reward neurocircuitry and the 'dark side' of drug addiction.

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  • 1Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, 92037, USA.


Drug seeking is associated with activation of reward neural circuitry. Here we argue that drug addiction also involves a 'dark side'--a decrease in the function of normal reward-related neurocircuitry and persistent recruitment of anti-reward systems. Understanding the neuroplasticity of the dark side of this circuitry is the key to understanding vulnerability to addiction.

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