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Nat Neurosci. 2005 Nov;8(11):1442-4.

Plasticity of reward neurocircuitry and the 'dark side' of drug addiction.

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  • 1Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, 92037, USA. gkoob@scripps.edu

Abstract

Drug seeking is associated with activation of reward neural circuitry. Here we argue that drug addiction also involves a 'dark side'--a decrease in the function of normal reward-related neurocircuitry and persistent recruitment of anti-reward systems. Understanding the neuroplasticity of the dark side of this circuitry is the key to understanding vulnerability to addiction.

PMID:
16251985
[PubMed - indexed for MEDLINE]
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