J Dermatolog Treat. 2005;16(4):242-4.

Treatment of Kimura's disease with cyclosporine.

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Division of Dermatology, Department of Laboratory Medicine, Changi General Hospital, Singapore.

Abstract

Kimura's disease is a rare, chronic inflammatory disease of unknown cause. It is characterized by painless subcutaneous swellings and lymphadenopathy, commonly affecting the head and neck region. This is associated with peripheral blood eosinophilia and raised serum IgE. It has distinct histological features of lymphoid follicles, eosinophilic infiltrate, fibrosis and vascular proliferation. The disease usually has a benign, indolent course. Traditionally, therapeutic options have included surgery, radiotherapy and steroids but response has been less than satisfactory. Recently, cyclosporine has been reported to be effective in the treatment of Kimura's disease. In this article, we present a middle-aged Chinese female with Kimura's disease for 20 years and her favourable response to cyclosporine.

PMID:: 16249147; [PubMed - indexed for MEDLINE]

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Kimura's disease. Involvement of regional lymph nodes and distinction from angiolymphoid hyperplasia with eosinophilia. [Am J Surg Pathol. 1988]
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Cited by 2 PubMed Central articles

An Unusual Clinical Presentation of Kimura's Disease Occurring on the Buttock of a Five-year-old Boy. [Ann Dermatol. 2010]
An Unusual Clinical Presentation of Kimura's Disease Occurring on the Buttock of a Five-year-old Boy.
Choi WJ, Hur J, Ko JY, Yeo KY, Kim JS, Yu HJ. Ann Dermatol. 2010 Feb; 22(1):57-60. Epub 2010 Feb 28.
Kimura's disease involving the ipsilateral face and extraocular muscles. [Korean J Ophthalmol. 2009]
Kimura's disease involving the ipsilateral face and extraocular muscles.
Lee SJ, Song JH, Kim SD. Korean J Ophthalmol. 2009 Sep; 23(3):219-23. Epub 2009 Sep 9.

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