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Mol Cell. 2005 Oct 28;20(2):168-70.

E Pluribus Unum: 3' end formation of polyadenylated mRNAs, histone mRNAs, and U snRNAs.

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  • Department of Biochemistry, School of Medicine, University of Washington, Seattle, Washington 98195, USA.


The 3' ends of almost all eukaryotic RNAs are generated by nucleolytic cleavage. Remarkably, three groups now demonstrate that similar or identical endonucleases of the metallo-beta-lactamase family generate the 3' ends of polyadenylated mRNAs, nonpolyadenylated histone mRNAs, and U snRNAs.

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