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    Bioorg Med Chem Lett. 2006 Jan 15;16(2):293-6. Epub 2005 Oct 21.

    4-hydroxyisoleucine an unusual amino acid as antidyslipidemic and antihyperglycemic agent.

    Source

    Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, India. tnarender@rediffmail.com

    Abstract

    Trigonella foenum-graecum, commonly known as fenugreek, is an annual herbaceous plant. From the seeds of T. foenum-graecum an unusual amino acid, 4-hydroxyisoleucine 5, has been isolated, which significantly decreased the plasma triglyceride levels by 33% (P<0.002), total cholesterol (TC) by 22% (P<0.02), and free fatty acids by 14%, accompanied by an increase in HDL-C/TC ratio by 39% in the dyslipidemic hamster model.

    PMID:
    16246556
    [PubMed - indexed for MEDLINE]

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