Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell Biochem Biophys. 2005;43(3):439-49.

Cytoskeletal regulation of nitric oxide synthase.

Author information

  • 1Department of Medicine, MSB M452, Box 100225, University of Florida, 1600 S.W. Archer Road, Gainesville, FL 32610, USA. ysu@ufl.edu

Abstract

The three isoforms of nitric oxide synthase (NOS)--endothelial NOS (eNOS), inducible NOS (iNOS), and neural NOS (nNOS)--colocalize with the cytoskeleton including actin microfilaments, microtubules, and intermediate filaments directly or indirectly. These colocalizations enable optimal nitric oxide production and help NOS exert their functions. The reorganization of cytoskeletal polymerization state induced by extracellular stimuli such as shear stress, hypoxia, and drugs regulates eNOS, nNOS, and iNOS. Alterations of nitric oxide production caused by cytoskeletal reorganization play an important role in physiological and pathophysiological conditions. This review focuses on recent data regarding the regulation of NOS by the cytoskeleton at transcriptional, posttranscriptional, and posttranslational levels.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Write to the Help Desk