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Drug Discov Today. 2005 Nov 1;10(21):1475-82.

Beyond annotation transfer by homology: novel protein-function prediction methods to assist drug discovery.

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  • 1CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.


Every entirely sequenced genome reveals 100 s to 1000 s of protein sequences for which the only annotation available is 'hypothetical protein'. Thus, in the human genome and in the genomes of pathogenic agents there could be 1000 s of potential, unexplored drug targets. Computational prediction of protein function can play a role in studying these targets. We shall review the challenges, research approaches and recently developed tools in the field of computational function-prediction and we will discuss the ways these issues can change the process of drug discovery.

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