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Curr Opin Chem Biol. 2005 Dec;9(6):632-8. Epub 2005 Oct 18.

Protein surface recognition and proteomimetics: mimics of protein surface structure and function.

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  • 1Department of Chemistry, Yale University, CT 06520-8107, USA.


Due to their key roles in a number of biological processes, protein-protein interactions are attractive and important targets, typically involving areas greater than 6 nm2. The disruption of such interactions remains a challenging feat but, in recent years, there has been considerable progress in the design of proteomimetics: molecules that mimic the structure and function of extended regions of protein surfaces. In particular, porphyrins, calixarenes, alpha-helical mimetics and small molecules have successfully modulated significant protein-protein interactions, including those involved in cancer and HIV.

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