Int J Immunopharmacol. 1992 Feb;14(2):159-65.

Muramyl dipeptide-induced changes in murine splenocyte responses to concanavalin A.

Dozmorov IM, Bagaeva LV, Kuzin II, Sapozhnikov AM, Svirshchevskaya EV, Andronova TM, Petrov RV.

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Department of Immunology, Shemyakin Institute of Bioorganic Chemistry, Moscow, USSR Academy of Sciences.

Abstract

The effect of muramyl dipeptide (MDP) on Con A-stimulated activation of murine spleen cells was studied. MDP was found to enhance or suppress the proliferative response of splenocytes when different concentrations of Con A were used. MDP was shown to change the IL-2 content in culture supernatants of stimulated cells and to influence IL-2-dependent proliferation of Con A-blasts. A high degree of correlation was found between the proliferation of Con A-blasts and the expression of IL-2 receptors on Con A-blasts. This correlation, however, disappeared in the presence of MDP. The effects of MDP were shown to depend on the level of initial cell activity or rather on conditions leading to a given initial activity of cells.

PMID:: 1624217; [PubMed - indexed for MEDLINE]

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Muramyl dipeptide-induced changes in murine splenocyte responses to concanavalin A.

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