Ment Retard Dev Disabil Res Rev. 2005;11(4):286-94.

Mental retardation genes in drosophila: New approaches to understanding and treating developmental brain disorders.

Source

ARL Division of Neurobiology, University of Arizona, and Department of Neurology, Arizona Health Sciences Center, Tucson Arizona 85721-0077, USA. LLR@neurobio.arizona.edu

Abstract

Drosophila melanogaster is emerging as a valuable genetic model system for the study of mental retardation (MR). MR genes are remarkably similar between humans and fruit flies. Cognitive behavioral assays can detect reductions in learning and memory in flies with mutations in MR genes. Neuroanatomical methods, including some at single-neuron resolution, are helping to reveal the cellular bases of faulty brain development caused by MR gene mutations. Drosophila fragile X mental retardation 1 (dfmr1) is the fly counterpart of the human gene whose malfunction causes fragile X syndrome. Research on the fly gene is leading the field in molecular mechanisms of the gene product's biological function and in pharmacological rescue of brain and behavioral phenotypes. Future work holds the promise of using genetic pathway analysis and primary neuronal culture methods in Drosophila as tools for drug discovery for a wide range of MR and related disorders.

PMID:: 16240406; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Defective neuronal development in the mushroom bodies of Drosophila fragile X mental retardation 1 mutants. [J Neurosci. 2004]
Defective neuronal development in the mushroom bodies of Drosophila fragile X mental retardation 1 mutants.
Michel CI, Kraft R, Restifo LL. J Neurosci. 2004 Jun 23; 24(25):5798-809.
Genetic and systems level analysis of Drosophila sticky/citron kinase and dFmr1 mutants reveals common regulation of genetic networks. [BMC Syst Biol. 2008]
Genetic and systems level analysis of Drosophila sticky/citron kinase and dFmr1 mutants reveals common regulation of genetic networks.
Bauer CR, Epstein AM, Sweeney SJ, Zarnescu DC, Bosco G. BMC Syst Biol. 2008 Nov 25; 2:101. Epub 2008 Nov 25.
Review RNA interference: a new mechanism by which FMRP acts in the normal brain? What can Drosophila teach us? [Ment Retard Dev Disabil Res Re...]
Review RNA interference: a new mechanism by which FMRP acts in the normal brain? What can Drosophila teach us?
Siomi H, Ishizuka A, Siomi MC. Ment Retard Dev Disabil Res Rev. 2004; 10(1):68-74.
Argonaute2 suppresses Drosophila fragile X expression preventing neurogenesis and oogenesis defects. [PLoS One. 2009]
Argonaute2 suppresses Drosophila fragile X expression preventing neurogenesis and oogenesis defects.
Pepper AS, Beerman RW, Bhogal B, Jongens TA. PLoS One. 2009 Oct 27; 4(10):e7618. Epub 2009 Oct 27.
Review The behavioral neurogenetics of fragile X syndrome: analyzing gene-brain-behavior relationships in child developmental psychopathologies. [Dev Psychopathol. 2003]
Review The behavioral neurogenetics of fragile X syndrome: analyzing gene-brain-behavior relationships in child developmental psychopathologies.
Reiss AL, Dant CC. Dev Psychopathol. 2003 Fall; 15(4):927-68.

See reviews... See all...

Cited by 9 PubMed Central articles

In Vivo Effects Of Traditional Ayurvedic Formulations in Drosophila melanogaster Model Relate with Therapeutic Applications. [PLoS One. 2012]
In Vivo Effects Of Traditional Ayurvedic Formulations in Drosophila melanogaster Model Relate with Therapeutic Applications.
Dwivedi V, Anandan EM, Mony RS, Muraleedharan TS, Valiathan MS, Mutsuddi M, Lakhotia SC. PLoS One. 2012; 7(5):e37113. Epub 2012 May 14.
Drosophila as a model for MECP2 gain of function in neurons. [PLoS One. 2012]
Drosophila as a model for MECP2 gain of function in neurons.
Vonhoff F, Williams A, Ryglewski S, Duch C. PLoS One. 2012; 7(2):e31835. Epub 2012 Feb 21.
Teasing apart the heterogeneity of autism: Same behavior, different brains in toddlers with fragile X syndrome and autism. [J Neurodev Disord. 2009]
Teasing apart the heterogeneity of autism: Same behavior, different brains in toddlers with fragile X syndrome and autism.
Hazlett HC, Poe MD, Lightbody AA, Gerig G, Macfall JR, Ross AK, Provenzale J, Martin A, Reiss AL, Piven J. J Neurodev Disord. 2009 Mar; 1(1):81-90.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Mental retardation genes in drosophila: New approaches to understanding and trea...
Mental retardation genes in drosophila: New approaches to understanding and treating developmental brain disorders.
Ment Retard Dev Disabil Res Rev. 2005 ;11(4):286-94.

PubMed
OPA1 R445H mutation in optic atrophy associated with sensorineural deafness.
OPA1 R445H mutation in optic atrophy associated with sensorineural deafness.
Ann Neurol. 2005 Dec ;58(6):958-63.

PubMed
Developing and implementing future stroke therapies: the potential of telemedici...
Developing and implementing future stroke therapies: the potential of telemedicine.
Ann Neurol. 2005 Nov ;58(5):666-71.

PubMed
[Usability of self-tonometry under ambulatory conditions to obtain daily profile...
[Usability of self-tonometry under ambulatory conditions to obtain daily profiles of intraocular pressure at home].
Klin Monbl Augenheilkd. 2005 Oct ;222(10):814-21.

PubMed
[Value of radiological methods in the diagnosis of biliary diseases].
[Value of radiological methods in the diagnosis of biliary diseases].
Radiologe. 2005 Nov ;45(11):976-8, 980-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Mental retardation genes in drosophila: New approaches to understanding and treating developmental brain disorders.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 9 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information