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Science. 2005 Oct 21;310(5747):496-8.

Interlinked fast and slow positive feedback loops drive reliable cell decisions.

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  • 1Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA, 94305, USA. onn@stanford.edu

Abstract

Positive feedback is a ubiquitous signal transduction motif that allows systems to convert graded inputs into decisive, all-or-none outputs. Here we investigate why the positive feedback switches that regulate polarization of budding yeast, calcium signaling, Xenopus oocyte maturation, and various other processes use multiple interlinked loops rather than single positive feedback loops. Mathematical simulations revealed that linking fast and slow positive feedback loops creates a "dual-time" switch that is both rapidly inducible and resistant to noise in the upstream signaling system.

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PMID:
16239477
[PubMed - indexed for MEDLINE]
PMCID:
PMC3175767
Free PMC Article
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