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J Biosci Bioeng. 2002;94(6):591-9.

Plant cell culture for production of paclitaxel and other taxanes.

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  • 1State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.


Great advances in cell cultures of Taxus spp. for production of Taxol (generic name: paclitaxel) and other taxanes (taxoids) have been achieved in the past decade. This article reviews the manipulation of inducing factors--elicitors, gas composition, osmotic pressure, and conditioned medium; bioprocessing strategies--combining of inducing techniques, two-phase and two-stage cultivation, semi-continuous and perfusion cultures, and feeding of precursors or sugars; and bioreactors and scale-up. Perspectives on a more rational and efficient process involving metabolic engineering are also discussed.

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