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Ann Biol Clin (Paris). 2005 Sep-Oct;63(5):525-9.

[Evaluation of rapid, semi-quantitative assay of C-reactive protein in whole blood, Actim CRP].

[Article in French]

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  • 1Laboratoire de biochimie médicale, Hôtel-Dieu, CHU de Clermont-Ferrand.


We evaluated a rapid and semi-quantitative C-Reactive Protein test on whole blood, the Actim CRP (Fumouze). Based on immuno-chromatography technology, this test ranked the blood sample in four groups: < 10 mg/L, 10-40 mg/L, 40-80 mg/L and > 80 mg/L. This evaluation finds an excellent repeatability, the absence of hook-effect for high levels of CRP and an independence from classical biological interferences: haemolysis, turbidity and bilirubin. The correlation is excellent between the rapid test and classical immuno-turbidimetric plasmatic CRP assay. This test with established analytical properties could be placed as an interesting alternative to replace the classical assays realised on analysers, and more particularly in case of reduced sample volume. The use in "patient care" context had to follow rigorous manufacturer's recommendations to respect analytical specificities identified during our validation process.

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