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    Cancer Lett. 2006 Aug 18;240(1):41-7. Epub 2005 Oct 17.

    Association of BCL10 germ line polymorphisms on chromosome 1p with advanced stage testicular germ cell tumor patients.

    Inoue T, Ito T, Narita S, Horikawa Y, Tsuchiya N, Kakinuma H, Mishina M, Nakamura E, Kato T, Ogawa O, Habuchi T.

    Source

    Department of Urology, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.

    Abstract

    The association between four BCL10 single nucleotide polymorphisms at codons 5, 8, 162, and intron 1 and the susceptibility or progression for germ cell tumors (GCTs) was investigated in 73 testicular GCT patients and 72 controls. GCT patients with metastatic disease were more likely to have a variant type allele of the polymorphisms at codon 5 (age-adjusted odds ratio (aOR)=6.25; 95% CI=1.09-35.83; P=0.040) and codon 8 (aOR=4.63; 95% CI=1.35-15.93; P=0.015) than those with the localized disease. Therefore, BCL10 polymorphisms at codons 5 and 8 may play a role in the progression to advanced stage GCTs.

    PMID:
    16229939
    [PubMed - indexed for MEDLINE]

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