Your browser version may not work well with NCBI's Web applications. More information here...
1: Vaccine. 2006 Feb 27;24(9):1483-7. Epub 2005 Oct 3.Click here to read Links

Evaluation of the Brighton Collaboration case definition of acute intussusception during active surveillance.

Tapiainen T, Bär G, Bonhoeffer J, Heininger U.

University Children Hospital, Division of Pediatrics Infectious Diseases and Vaccines, Post Box, 4005 Basel, Switzerland.

To evaluate the Brighton Collaboration case definition of acute intussusception, we reviewed all episodes reported to the Swiss Paediatric Surveillance Unit (SPSU) during 1 year (4/2003--3/2004). Of 96 confirmed episodes 86 (90%, 95% CI 83--96) were captured by the case definition. Of the remaining 10 episodes, 9 resolved spontaneously following presentation with clinical signs and symptoms, and ultrasound findings compatible with intussusception. Eighty-two episodes met level 1 of the definition, the highest level of diagnostic certainty. Compared to level 1, the sensitivity of level 2 (intermediate level) and level 3 (lowest level) was 65% (CI 55--74) and 30% (CI 20--40), respectively. In conclusion, the case definition was useful and applicable to assess the background rate of intussusception in the light of potential future rotavirus immunization.

PMID: 16226829 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Rotavirus Vaccine (Rotarix® , RotaTeq® )

    Rotavirus is a virus that causes severe diarrhea, mostly in babies and young children. It is often accompanied by vomiting and fever. Rotavirus is not the only cause of severe diarrhea, but it is one of the most serious....

  • Source: AHFS Consumer Medication Information