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Int J Gynaecol Obstet. 2005 Dec;91(3):228-32. Epub 2005 Oct 14.

Sublingual nitroglycerin for management of retained placenta.

Author information

  • 1Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Göteborg, Sweden.

Erratum in

  • Int J Gynaecol Obstet. 2006 Mar;92(3):337.



The aim of the study was to investigate the effect of sublingual nitroglycerin for management of retained placenta and to assess possible adverse effects of the treatment.


Twenty-four women were randomly selected to receive either 1 mg nitroglycerin or placebo tablets sublingually if intravenous oxytocin and controlled umbilical cord traction had failed to expel the placenta. Success rate for delivery of placenta, blood pressure, pulse rate, blood loss, and various side effects were examined.


All 12 women in the nitroglycerin group had successful delivery of placenta, while removal of placenta was successful in only one of the 12 women in the placebo group. No adverse effects of clinical importance were registered.


Sublingual nitroglycerin for treatment of retained placenta seems to be effective without causing serious adverse effects. However, the definite clinical value needs to be evaluated in larger series of patients.

[PubMed - indexed for MEDLINE]
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