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1: Science. 2005 Oct 14;310(5746):321-4.Click here to read Links
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Science. 2005 Oct 14;310(5746):247-8.

A fine-scale map of recombination rates and hotspots across the human genome.

Myers S, Bottolo L, Freeman C, McVean G, Donnelly P.

Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.

Genetic maps, which document the way in which recombination rates vary over a genome, are an essential tool for many genetic analyses. We present a high-resolution genetic map of the human genome, based on statistical analyses of genetic variation data, and identify more than 25,000 recombination hotspots, together with motifs and sequence contexts that play a role in hotspot activity. Differences between the behavior of recombination rates over large (megabase) and small (kilobase) scales lead us to suggest a two-stage model for recombination in which hotspots are stochastic features, within a framework in which large-scale rates are constrained.

PMID: 16224025 [PubMed - indexed for MEDLINE]

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