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Science. 2005 Oct 14;310(5746):247-8.

Genetics. Motivating hotspots.

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  • Department of Human Genetics, University of Chicago, 920 East 57th Street, 507F CLSC, Chicago, IL 60637, USA. mfp@uchicago.edu


Only recently have we begun to characterize fine-scale recombination rates in mammals. In her Perspective, Przeworski discusses the work by Myers et al. in which linkage disequilibrium data have been used to produce a high-resolution recombination map for most of the human genome. More than 25,000 putative hotspots have been identified, as well as the first motifs that appear to influence their intensity.

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