Nutr Rev. 2005 Sep;63(9):315-9.

Is GAD2 on chromosome 10p12 a potential candidate gene for morbid obesity?

Tiwari HK, Bouchard L, Pérusse L, Allison DB.

Source

Department of Biostatistics, Section on Statistical Genetics, University of Alabama, Birmingham 35294, USA. htiwari@UAB.edu

Abstract

Morbidly obese individuals represent one of the fastest growing subpopulations of obese individuals. Thus, it is of significant interest to broaden our understanding of the potential genetic causes of this public health concern. A recent study investigated a role of positional candidate gene GAD2 (the gene for glutamic acid decarboxylase) in the development of morbid obesity. This commentary carefully examines the genetic and functional arguments for and against the GAD2 gene as an influential gene for obesity. Also discussed are additional research questions that merit inquiry when further evaluating this genetic variant as a putative contributor to human obesity.

PMID:: 16220643; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

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Substances

Glutamate Decarboxylase

Grant Support

P30DK056336/DK/NIDDK NIH HHS/United States

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Genes and Gene Therapy - MedlinePlus Health Information

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