Abstract
Enantiomerically pure (R)-2-chloro-1-(pyridin-3-yl)ethanol has been prepared by kinetic resolution performed in the presence of Candida antarctica SP435-L lipase immobilized on a macroporous polyacrylate resin (Novozym 435). It was converted into (R)-1-(pyridin-3-yl)-2-aminoethanol, left-hand side of beta(3)-adrenergic receptor ligands.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic beta-3 Receptor Agonists*
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Candida / enzymology
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Enzymes, Immobilized / metabolism
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Ethanolamines / chemical synthesis*
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Ethanolamines / chemistry
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Ethanolamines / pharmacology*
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Kinetics
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Lipase / metabolism*
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Models, Molecular
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Pyridines / chemical synthesis*
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Pyridines / chemistry
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Pyridines / pharmacology*
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Receptors, Adrenergic, beta-3 / metabolism
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Stereoisomerism
Substances
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(R)-1-(pyridin-3-yl)-2-aminoethanol
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Adrenergic beta-3 Receptor Agonists
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Enzymes, Immobilized
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Ethanolamines
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Pyridines
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Receptors, Adrenergic, beta-3
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Lipase