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Curr Psychiatry Rep. 2005 Oct;7(5):376-80.

Treatment approaches to symptoms associated with frontotemporal degeneration.

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  • 1The Rotman Research Institute, 3560 Bathurst Street, 8th Floor, Posluns Building, Toronto, Ontario M6A 2E1, Canada.


A systematic review of the literature reveals few randomized, controlled trials for drug therapy in frontotemporal degeneration (FTD). Although there is evidence to support a serotonergic deficit, and clinicians frequently prescribe selective serotonin reuptake inhibitors to patients with FTD, only paroxetine and trazodone have been studied. There is Class II evidence for use of rivastigmine in FTD behavioral disturbances, although there is no consistent evidence of cholinergic deficit in this illness.

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