FEBS Lett. 2005 Oct 31;579(26):5904-10. Epub 2005 Sep 30.

Prediction and validation of microRNAs and their targets.

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Rosetta Genomics Ltd., 10 Plaut Street, Science Park, Rehovot 76706, Israel.

Abstract

MicroRNAs are short non-coding RNAs that inhibit translation of target genes by binding to their mRNAs, and have been shown to play a central role in gene regulation in health and disease. Sophisticated computer-based prediction approaches of microRNAs and of their targets, and effective biological validation techniques for validating these predictions, now play a central role in discovery of microRNAs and elucidating their functions.

PMID:: 16214134; [PubMed - indexed for MEDLINE]

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Prediction and validation of microRNAs and their targets.

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