Antiplasmodial diterpenoid from the leaves of Hyptis suaveolens

J C Chukwujekwu; P Smith; P H Coombes; D A Mulholland; J van Staden

doi:10.1016/j.jep.2005.08.018

Antiplasmodial diterpenoid from the leaves of Hyptis suaveolens

J Ethnopharmacol. 2005 Nov 14;102(2):295-7. doi: 10.1016/j.jep.2005.08.018. Epub 2005 Oct 5.

Authors

J C Chukwujekwu¹, P Smith, P H Coombes, D A Mulholland, J van Staden

Affiliation

¹ Research Centre for Plant Growth and Development, School of Biological and Conservation Sciences, University of KwaZulu-Natal Pietermaritzburg, Private Bag X0l, Scottsville 3209, South Africa.

PMID: 16213121
DOI: 10.1016/j.jep.2005.08.018

Abstract

Bioactivity-guided fractionation of the petroleum ether extract of the leaves of Hyptis suaveolens, widely used in Traditional Medicine, has led to the isolation of an abietane-type diterpenoid endoperoxide, 13 alpha-epi-dioxiabiet-8(14)-en-18-ol, displaying high antiplasmodial activity (IC(50) 0.1 microg/ml).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antimalarials / isolation & purification
Antimalarials / pharmacology*
Diterpenes / isolation & purification
Diterpenes / pharmacology*
Hyptis / chemistry*
Plant Leaves / chemistry*
Plasmodium falciparum / drug effects

Substances

Antimalarials
Diterpenes