Annu Rev Cell Dev Biol. 2005;21:695-718.

The great escape: when cancer cells hijack the genes for chemotaxis and motility.

Source

Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461-1975, USA. condeeli@aecom.yu.edu

Abstract

The combined use of the new technologies of multiphoton-based intravital imaging, the chemotaxis-mediated collection of invasive cells, and high sensitivity expression profiling has allowed the correlation of the behavior of invasive tumor cells in vivo with their gene expression patterns. New insights have resulted including a gene expression signature for invasive cells and the tumor microenvironment invasion model. This model proposes that tumor invasion and metastasis can be studied as a problem resembling normal morphogenesis. We discuss how these new insights may lead to a better understanding of the molecular basis of the invasive behavior of tumor cells in vivo, which may result in new strategies for the diagnosis and treatment of metastasis.

PMID:: 16212512; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

Review

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors. [Cancer Res. 2007]
Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors.
Wang W, Wyckoff JB, Goswami S, Wang Y, Sidani M, Segall JE, Condeelis JS. Cancer Res. 2007 Apr 15; 67(8):3505-11.
Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling. [Cancer Res. 2002]
Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling.
Wang W, Wyckoff JB, Frohlich VC, Oleynikov Y, Hüttelmaier S, Zavadil J, Cermak L, Bottinger EP, Singer RH, White JG, et al. Cancer Res. 2002 Nov 1; 62(21):6278-88.
Tumor cells caught in the act of invading: their strategy for enhanced cell motility. [Trends Cell Biol. 2005]
Tumor cells caught in the act of invading: their strategy for enhanced cell motility.
Wang W, Goswami S, Sahai E, Wyckoff JB, Segall JE, Condeelis JS. Trends Cell Biol. 2005 Mar; 15(3):138-45.
Review Cell migration and metastasis as targets of small RNA-based molecular genetic analyses. [J Muscle Res Cell Motil. 2004]
Review Cell migration and metastasis as targets of small RNA-based molecular genetic analyses.
Suyama E, Kawasaki H, Wadhwa R, Taira K. J Muscle Res Cell Motil. 2004; 25(4-5):303-8.
Review Molecular basis of invasion in breast cancer. [Cell Mol Life Sci. 2007]
Review Molecular basis of invasion in breast cancer.
McSherry EA, Donatello S, Hopkins AM, McDonnell S. Cell Mol Life Sci. 2007 Dec; 64(24):3201-18.

See reviews... See all...

Cited by 49 PubMed Central articles

Mass homozygotes accumulation in the NCI-60 cancer cell lines as compared to HapMap Trios, and relation to fragile site location. [PLoS One. 2012]
Mass homozygotes accumulation in the NCI-60 cancer cell lines as compared to HapMap Trios, and relation to fragile site location.
Ruan X, Kocher JP, Pommier Y, Liu H, Reinhold WC. PLoS One. 2012; 7(2):e31628. Epub 2012 Feb 9.
Intravital microscopy in the mouse dorsal chamber model for the study of solid tumors. [Am J Cancer Res. 2011]
Intravital microscopy in the mouse dorsal chamber model for the study of solid tumors.
Baron VT, Welsh J, Abedinpour P, Borgström P. Am J Cancer Res. 2011; 1(5):674-86. Epub 2011 May 1.
Quantifying information transmission in eukaryotic gradient sensing and chemotactic response. [J Stat Phys. 2011]
Quantifying information transmission in eukaryotic gradient sensing and chemotactic response.
Hu B, Chen W, Levine H, Rappel WJ. J Stat Phys. 2011 Apr 1; 142(6):1167-1186.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The great escape: when cancer cells hijack the genes for chemotaxis and motility...
The great escape: when cancer cells hijack the genes for chemotaxis and motility.
Annu Rev Cell Dev Biol. 2005 ;21:695-718.

PubMed
Protein translocation by the Sec61/SecY channel.
Protein translocation by the Sec61/SecY channel.
Annu Rev Cell Dev Biol. 2005 ;21:529-50.

PubMed
RNA silencing systems and their relevance to plant development.
RNA silencing systems and their relevance to plant development.
Annu Rev Cell Dev Biol. 2005 ;21:297-318.

PubMed
Assembly of variant histones into chromatin.
Assembly of variant histones into chromatin.
Annu Rev Cell Dev Biol. 2005 ;21:133-53.

PubMed
Principles of lysosomal membrane digestion: stimulation of sphingolipid degradat...
Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids.
Annu Rev Cell Dev Biol. 2005 ;21:81-103.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: