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Annu Rev Cell Dev Biol. 2005;21:247-69.

Rho GTPases: biochemistry and biology.

Author information

  • 1MRC Laboratory for Molecular Cell Biology, Cancer Research UK, Oncogene and Signal Transduction Group, United Kingdom. a.jaffe@ucl.ac.uk

Abstract

Approximately one percent of the human genome encodes proteins that either regulate or are regulated by direct interaction with members of the Rho family of small GTPases. Through a series of complex biochemical networks, these highly conserved molecular switches control some of the most fundamental processes of cell biology common to all eukaryotes, including morphogenesis, polarity, movement, and cell division. In the first part of this review, we present the best characterized of these biochemical pathways; in the second part, we attempt to integrate these molecular details into a biological context.

PMID:
16212495
[PubMed - indexed for MEDLINE]
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