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J Org Chem. 2005 Oct 14;70(21):8395-9.

Multicomponent synthesis of spiroisoxazolines.

Author information

  • 1Centre for Synthesis and Chemical Biolog, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, Dublin 2, Dublin, Ireland. madamo@rcsi.ie

Abstract

A three-component one-pot procedure (3-MCR) was developed to assemble the spiroisoxazoline nucleus from commercially available materials. This new methodology affords the title compounds in high yields and without the use of chromatography.

PMID:
16209583
[PubMed - indexed for MEDLINE]
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