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Genome Biol. 2005;6(10):233. Epub 2005 Sep 29.

Global approaches to understanding ubiquitination.

Author information

  • 1Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA 92697-1700, USA. pkaiser@uci.edu

Abstract

Ubiquitination--the linkage of one or more molecules of the protein ubiquitin to another protein--regulates a wide range of biological processes in all eukaryotes. We review the proteome-wide strategies that are being used to study aspects of ubiquitin biology, including substrates, components of the proteasome and ubiquitin ligases, and deubiquitination.

PMID:
16207362
[PubMed - indexed for MEDLINE]
PMCID:
PMC1257457
Free PMC Article

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