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1: Genome Biol. 2005;6(10):233. Epub 2005 Sep 29.Click here to read Click here to read Links

Global approaches to understanding ubiquitination.

Kaiser P, Huang L.

Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA 92697-1700, USA. pkaiser@uci.edu

Ubiquitination--the linkage of one or more molecules of the protein ubiquitin to another protein--regulates a wide range of biological processes in all eukaryotes. We review the proteome-wide strategies that are being used to study aspects of ubiquitin biology, including substrates, components of the proteasome and ubiquitin ligases, and deubiquitination.

PMID: 16207362 [PubMed - indexed for MEDLINE]

PMCID: PMC1257457