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Genome Biol. 2005;6(10):R88. Epub 2005 Sep 19.

Searching for differentially expressed gene combinations.

Author information

  • 1Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA. dettling@jhu.edu

Abstract

We propose 'CorScor', a novel approach for identifying gene pairs with joint differential expression. This is defined as a situation with good phenotype discrimination in the bivariate, but not in the two marginal distributions. CorScor can be used to detect phenotype-related dependencies and interactions among genes. Our easily interpretable approach is scalable to current microarray dimensions and yields promising results on several cancer-gene-expression datasets.

PMID:
16207359
[PubMed - indexed for MEDLINE]
PMCID:
PMC1257471
Free PMC Article

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