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    Biol Pharm Bull. 2005 Oct;28(10):1844-51.

    Hypotensive activity, toxicology and histopathology of opuntioside-I and methanolic extract of Opuntia dillenii.

    Saleem R, Ahmad M, Azmat A, Ahmad SI, Faizi Z, Abidi L, Faizi S.

    Source

    Faculty of Pharmacy, Hamdard University; Karachi, Pakistan. rs127pk@yahoo.com

    Abstract

    Methanolic extract of Opuntia dillenii cladodes and its pure compound alpha-pyrone glycoside, opuntioside-I showed potent hypotensive activity in normotensive rats. Both the extract and opuntioside-I showed comparable effect of 44-54% fall in Mean Arterial Blood Pressure (MABP) at the dose of 10 mg/kg. No mortality was observed in rats even at the doses of 1000 mg/kg/d and 900 mg/kg/d per oral of extract and opuntioside-I respectively. However, histopathology revealed adverse effects of high doses on liver and spleen of the experimental animals.

    PMID:
    16204933
    [PubMed - indexed for MEDLINE]
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