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Genes Dev. 2005 Oct 1;19(19):2289-94.

Global regulation of X chromosomal genes by the MSL complex in Drosophila melanogaster.

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  • 1Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

Abstract

A long-standing model postulates that X-chromosome dosage compensation in Drosophila occurs by twofold up-regulation of the single male X, but previous data cannot exclude an alternative model, in which male autosomes are down-regulated to balance gene expression. To distinguish between the two models, we used RNA interference to deplete Male-Specific Lethal (MSL) complexes from male-like tissue culture cells. We found that expression of many genes from the X chromosome decreased, while expression from the autosomes was largely unchanged. We conclude that the primary role of the MSL complex is to up-regulate the male X chromosome.

PMID:
16204180
[PubMed - indexed for MEDLINE]
PMCID:
PMC1240037
Free PMC Article

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