Synthesis and biological evaluation of novel lipid...[Bioorg Med Chem. 2006]

SearchDatabase nameforSearch term

Advanced Search

Your browser version may not work well with NCBI's Web applications. More information here...

Display Show

All: 1

Review: 0

Click to change filter selection through MyNCBI.

1: Bioorg Med Chem. 2006 Jan 1;14(1):190-9. Epub 2005 Oct 3. Links

Synthesis and biological evaluation of novel lipid A antagonists.

Peri F, Marinzi C, Barath M, Granucci F, Urbano M, Nicotra F.

Department of Biotechnology and Biosciences, University of Milano-Bicocca, P.zza della Scienza 2, 20126 Milan, Italy. francesco.peri@unimib.it

A mimetic of Lipid A with a beta-N(OMe) glycosidic linkage, four linear C-14 hydrophobic chains and without phosphate groups has been prepared together with its beta-O-linked analogue. Both these molecules were active in inhibiting the inflammatory action of Escherichia coli lipid A on MT2 macrophages in a dose-dependent manner, while they were completely devoid of inflammatory activity.

PMID: 16203155 [PubMed - indexed for MEDLINE]

The obligate predatory Bdellovibrio bacteriovorus possesses a neutral lipid A containing alpha-D-Mannoses that replace phosphate residues: similarities and differences between the lipid As and the lipopolysaccharides of the wild type strain B. bacteriovorus HD100 and its host-independent derivative HI100.
J Biol Chem. 2003 Jul 25; 278(30):27502-12. Epub 2003 May 12.

[J Biol Chem. 2003]
Accumulation of a polyisoprene-linked amino sugar in polymyxin-resistant Salmonella typhimurium and Escherichia coli: structural characterization and transfer to lipid A in the periplasm.
J Biol Chem. 2001 Nov 16; 276(46):43132-44. Epub 2001 Sep 4.

[J Biol Chem. 2001]
Complete lipopolysaccharide of Plesiomonas shigelloides O74:H5 (strain CNCTC 144/92). 2. Lipid A, its structural variability, the linkage to the core oligosaccharide, and the biological activity of the lipopolysaccharide.
Biochemistry. 2006 Sep 5; 45(35):10434-47.

[Biochemistry. 2006]
ReviewAnalysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: An update covering the period 1999-2000.
Mass Spectrom Rev. 2006 Jul-Aug; 25(4):595-662.

[Mass Spectrom Rev. 2006]
ReviewMethods in enzymology: O-glycosylation of proteins.
Methods Enzymol. 2005; 405:139-71.

[Methods Enzymol. 2005]
» See reviews... | » See all...

Recent Activity

Clear Turn Off Turn On

Synthesis and biological evaluation of novel lipid A antagonists.Synthesis and biological evaluation of novel lipid A antagonists.

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

Display Show

Synthesis and biological evaluation of novel lipid A antagonists.

Related articles

Recent Activity