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Int J Gynaecol Obstet. 2005 Dec;91(3):238-42. Epub 2005 Oct 3.

Histologic and clinical significance of atypical glandular cells on pap smears.

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  • 1Department of Obstetrics and Gynecology, University of Alberta, Canada.



To determine the association between atypical glandular cells (AGC) on Pap smear and clinically significant histology, in a large health region.


A cytologic database of over one million Pap smears was reviewed for a result of AGUS/AGC. Cytologic and histologic follow up was obtained to establish the presence of significant histology.


456 patients available for follow up had AGUS/AGC cytology results (0.043% of all Pap smear results). 197(45.2%) patients had a clinically significant diagnosis including 40 with adenocarcinoma in situ (AIS) of the cervix and 48 with endometrial cancer.


AGC on a Pap smear is frequently associated with a clinically significant diagnosis.

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