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Biol Chem. 2005 Aug;386(8):713-24.

Splicing of a rare class of introns by the U12-dependent spliceosome.

Author information

  • 1Max Planck Institute for Biophysical Chemistry, Department of Cellular Biochemistry, Am Fassberg 11, D-37077 Göttingen, Germany. cwill1@gwdg.de

Abstract

Pre-mRNA splicing is catalyzed by two unique spliceosomes, designated U2- or U12-dependent. In contrast to the well-characterized U2-dependent spliceosome, much remains to be learned about the less abundant U12-type spliceosome. This review focuses on recent advances in elucidating the structure and function of the minor U12-dependent spliceosome. Interesting similarities and differences between the U12- and U2-dependent spliceosomes are also highlighted.

PMID:
16201866
[PubMed - indexed for MEDLINE]
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