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J Clin Invest. 2005 Oct;115(10):2679-88.

Autophagy in cell death: an innocent convict?

Author information

  • 1Division of Infectious Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA. beth.levin@utsouthwestern.edu

Erratum in

  • J Clin Invest. 2006 Dec;116(12):3293.

Abstract

The visualization of autophagosomes in dying cells has led to the belief that autophagy is a nonapoptotic form of programmed cell death. This concept has now been evaluated using cells and organisms deficient in autophagy genes. Most evidence indicates that, at least in cells with intact apoptotic machinery, autophagy is primarily a pro-survival rather than a pro-death mechanism. This review summarizes the evidence linking autophagy to cell survival and cell death, the complex interplay between autophagy and apoptosis pathways, and the role of autophagy-dependent survival and death pathways in clinical diseases.

PMID:
16200202
[PubMed - indexed for MEDLINE]
PMCID:
PMC1236698
Free PMC Article
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