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Am J Psychiatry. 2005 Oct;162(10):1975-7.

Deficits on a probabilistic response-reversal task in patients with pediatric bipolar disorder.

Author information

  • 1Mood and Anxiety Program, National Institute of Mental Health, Bldg. 10, Rm. 4N-208, 10 Center Dr.-MSC 1255, Bethesda, MD 20892-1255, USA.

Abstract

OBJECTIVE:

Patients with bipolar disorder become hyperhedonic when manic and anhedonic when depressed; therefore, it is important to test whether patients with bipolar disorder show deficits on behavioral paradigms exploring reward/punishment mechanisms.

METHOD:

A probabilistic response-reversal task was administered to 24 bipolar children and 25 comparison subjects.

RESULTS:

Patients made more errors during probabilistic reversal, took longer to learn the new reward object, and were less likely to meet the learning criterion.

CONCLUSIONS:

Children with bipolar disorder may have a reversal learning deficit.

PMID:
16199850
[PubMed - indexed for MEDLINE]
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